MyBotsBlog -2M report

Chronologie Iphone S'abonner à notre Newsletter -Subscribe to our Newsletter Tue Jul 16 09:30:03 CEST 2024
15/07/24 Emploi direct : la PCH ne sert pas seulement a payer les salaires [faire-face]
15/07/24 Emploi direct : la PCH ne sert pas seulement a payer les salaires [faire-face]
12/07/24 Youth mental health is improving in Utah, survey finds [kslnewsradio]
12/07/24 Youth mental health is improving in Utah, survey finds [kslnewsradio]
12/07/24 Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder | Communications Biology [nature]
12/07/24 Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder | Communications Biology [nature]
27/06/24 STALICLA publishes pioneering phase 1b data on precision treatment for autism spectrum disorder in Biomedicines [tmcnet]
27/06/24 STALICLA publishes pioneering phase 1b data on precision treatment for autism spectrum disorder in Biomedicines [tmcnet]
25/06/24 Research: More Intervention May Not Benefit Autistic Children | Mirage News [miragenews]
25/06/24 Research: More Intervention May Not Benefit Autistic Children | Mirage News [miragenews]
21/06/24 Protein-based homing device precisely delivers drugs to target neurons [medicalxpress]
19/05/24 L'Etat condamne pour des heures de cours non remplacees : « Ils nous ont contraints d'en arriver la » - Le Parisien [leparisien]
18/05/24 Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings | Molecular Psychiatry [nature]


TED,Juridique
Emploi direct : la PCH ne sert pas seulement a payer les salaires [faire-face]
Emploi direct : la PCH ne sert pas seulement a payer les salaires [faire-face]

TED,Trends
Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder | Communications Biology [nature]
Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder | Communications Biology [nature]
Youth mental health is improving in Utah, survey finds [kslnewsradio]
Youth mental health is improving in Utah, survey finds [kslnewsradio]
STALICLA publishes pioneering phase 1b data on precision treatment for autism spectrum disorder in Biomedicines [tmcnet]
STALICLA publishes pioneering phase 1b data on precision treatment for autism spectrum disorder in Biomedicines [tmcnet]
Research: More Intervention May Not Benefit Autistic Children | Mirage News [miragenews]
Research: More Intervention May Not Benefit Autistic Children | Mirage News [miragenews]
Protein-based homing device precisely delivers drugs to target neurons [medicalxpress]
L'Etat condamne pour des heures de cours non remplacees : « Ils nous ont contraints d'en arriver la » - Le Parisien [leparisien]
Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings | Molecular Psychiatry [nature]

TED,Juridique
Emploi direct : la PCH ne sert pas seulement a payer les salaires 15/07/2024

«Fin juin, la Direction générale de la cohésion sociale a envoyé un courrier à tous les conseils départementaux. Elle leur précise que le tarif PCH emploi direct ne prend pas seulement en compte le salaire brut, les congés payés et toutes les cotisations patronales. Elle y liste toutes les autres charges que cette prestation a vocation à couvrir, des majorations de salaire les jours fériés aux indemnités de fin de CDD. Un rappel au droit qui sonne comme une avancée pour les particuliers employeurs.»
[...]
« Une liste des charges à couvrir par la PCH Fin juin, la Direction générale de la cohésion sociale (DGCS) a envoyé un courrier à tous les CD. Elle précise que le tarif PCH ne prend pas seulement en compte le salaire brut, les congés payés et toutes les cotisations patronales. Et y liste toutes les autres charges qu’elle a vocation à couvrir : – les majorations de salaires découlant de la convention collective, notamment pour heures supplémentaires, jours fériés et repos hebdomadaires : – les frais liés à la surveillance médicale des salariés, – la participation aux abonnements de transport public ou de service public de location de vélo, – le supplément de rémunération au titre du temps de conduite du salarié pour les besoins de ses activités professionnelles, – les indemnités kilométriques versées au salarié, – et le versement des indemnités de fin de contrat à durée déterminée. »...

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faire-face

Emploi direct : la PCH ne sert pas seulement a payer les salaires 15/07/2024

«Fin juin, la Direction générale de la cohésion sociale a envoyé un courrier à tous les conseils départementaux. Elle leur précise que le tarif PCH emploi direct ne prend pas seulement en compte le salaire brut, les congés payés et toutes les cotisations patronales. Elle y liste toutes les autres charges que cette prestation a vocation à couvrir, des majorations de salaire les jours fériés aux indemnités de fin de CDD. Un rappel au droit qui sonne comme une avancée pour les particuliers employeurs.»
[...]
« Une liste des charges à couvrir par la PCH Fin juin, la Direction générale de la cohésion sociale (DGCS) a envoyé un courrier à tous les CD. Elle précise que le tarif PCH ne prend pas seulement en compte le salaire brut, les congés payés et toutes les cotisations patronales. Et y liste toutes les autres charges qu’elle a vocation à couvrir : – les majorations de salaires découlant de la convention collective, notamment pour heures supplémentaires, jours fériés et repos hebdomadaires : – les frais liés à la surveillance médicale des salariés, – la participation aux abonnements de transport public ou de service public de location de vélo, – le supplément de rémunération au titre du temps de conduite du salarié pour les besoins de ses activités professionnelles, – les indemnités kilométriques versées au salarié, – et le versement des indemnités de fin de contrat à durée déterminée. »...

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faire-face

TED,Trends
Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder | Communications Biology 12/07/2024

«Abstract In autism spectrum disorder (ASD), atypical sensory experiences are often associated with irregularities in predictive coding, which proposes that the brain creates hierarchical sensory models via a bidirectional process of predictions and prediction errors. However, it remains unclear how these irregularities manifest across different functional hierarchies in the brain. To address this, we study a marmoset model of ASD induced by valproic acid (VPA) treatment. We record high-density electrocorticography (ECoG) during an auditory task with two layers of temporal control, and applied a quantitative model to quantify the integrity of predictive coding across two distinct hierarchies. Our results demonstrate a persistent pattern of sensory hypersensitivity and unstable predictions across two brain hierarchies in VPA-treated animals, and reveal the associated spatio-spectro-temporal neural signatures. Despite the regular occurrence of imprecise predictions in VPA-treated animals, we observe diverse configurations of underestimation or overestimation of sensory regularities within the hierarchies. Our results demonstrate the coexistence of the two primary Bayesian accounts of ASD: overly-precise sensory observations and weak prior beliefs, and offer a potential multi-layered biomarker for ASD, which could enhance our understanding of its diverse symptoms.»...

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nature

Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder | Communications Biology 12/07/2024

«Abstract In autism spectrum disorder (ASD), atypical sensory experiences are often associated with irregularities in predictive coding, which proposes that the brain creates hierarchical sensory models via a bidirectional process of predictions and prediction errors. However, it remains unclear how these irregularities manifest across different functional hierarchies in the brain. To address this, we study a marmoset model of ASD induced by valproic acid (VPA) treatment. We record high-density electrocorticography (ECoG) during an auditory task with two layers of temporal control, and applied a quantitative model to quantify the integrity of predictive coding across two distinct hierarchies. Our results demonstrate a persistent pattern of sensory hypersensitivity and unstable predictions across two brain hierarchies in VPA-treated animals, and reveal the associated spatio-spectro-temporal neural signatures. Despite the regular occurrence of imprecise predictions in VPA-treated animals, we observe diverse configurations of underestimation or overestimation of sensory regularities within the hierarchies. Our results demonstrate the coexistence of the two primary Bayesian accounts of ASD: overly-precise sensory observations and weak prior beliefs, and offer a potential multi-layered biomarker for ASD, which could enhance our understanding of its diverse symptoms.»...

<< Sommaire | Catégorie
nature

Youth mental health is improving in Utah, survey finds 12/07/2024

«SALT LAKE CITY Youth mental health is improving, the further away we get from the pandemic.That's according to new research from the Utah Department of Health and Human Services. The number of youth reporting depression is not small. But it is lower than it was the last time they asked.The latest Youth Risk Behavior Survey found that 37% of the respondents reported feeling so sad or hopeless that they changed their usual activities. It was more than 41% when students were surveyed in 2021.Utah officials said the number of teens feeling hopelessness spiked about six months after the pandemic started. They said that timing is consistent with societal trauma.»...

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kslnewsradio

Youth mental health is improving in Utah, survey finds 12/07/2024

«SALT LAKE CITY Youth mental health is improving, the further away we get from the pandemic.That's according to new research from the Utah Department of Health and Human Services. The number of youth reporting depression is not small. But it is lower than it was the last time they asked.The latest Youth Risk Behavior Survey found that 37% of the respondents reported feeling so sad or hopeless that they changed their usual activities. It was more than 41% when students were surveyed in 2021.Utah officials said the number of teens feeling hopelessness spiked about six months after the pandemic started. They said that timing is consistent with societal trauma.»...

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kslnewsradio

STALICLA publishes pioneering phase 1b data on precision treatment for autism spectrum disorder in Biomedicines 27/06/2024

«Geneva, Switzerland - June 27, 2024 - STALICLA SA, a Swiss neuro precision biotech company dedicated to developing precision medicine-based treatments for neuropsychiatric and neurodevelopmental disorders, today announced the publication of a landmark phase 1b study with STP1, a novel combination therapy tailored for the treatment of a clinically and biologically defined subgroup of patients with autism spectrum disorder (ASD), named ASD Phenotype 1 (ASD-Phen1).The results of the study were published in the peer-reviewed journal Biomedicines, in an article titled "Safety, Tolerability, and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist) in a Randomized Clinical Trial in a Subgroup of Patients with ASD".Lynn Durham, CEO of STALICLA, highlighted: "This study marks a significant milestone in the advancement of precision medicine for ASD. It is a first-of-its-kind stratification-based approach for clinical development in neurodevelopmental disorders, demonstrating the potential of precision medicine in ASD."The randomized, double-blind, placebo-controlled phase 1b clinical trial evaluated the safety and tolerability of STP1, a combination of ibudilast and bumetanide, in ASD-Phen1 patients. The clinical trial (registered at clinicaltrials.gov NCT04644003), involved two 14-day treatment phases of ASD-Phen1 patients receiving STP1 or placebo.»...

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tmcnet

STALICLA publishes pioneering phase 1b data on precision treatment for autism spectrum disorder in Biomedicines 27/06/2024

«Geneva, Switzerland - June 27, 2024 - STALICLA SA, a Swiss neuro precision biotech company dedicated to developing precision medicine-based treatments for neuropsychiatric and neurodevelopmental disorders, today announced the publication of a landmark phase 1b study with STP1, a novel combination therapy tailored for the treatment of a clinically and biologically defined subgroup of patients with autism spectrum disorder (ASD), named ASD Phenotype 1 (ASD-Phen1).The results of the study were published in the peer-reviewed journal Biomedicines, in an article titled "Safety, Tolerability, and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist) in a Randomized Clinical Trial in a Subgroup of Patients with ASD".Lynn Durham, CEO of STALICLA, highlighted: "This study marks a significant milestone in the advancement of precision medicine for ASD. It is a first-of-its-kind stratification-based approach for clinical development in neurodevelopmental disorders, demonstrating the potential of precision medicine in ASD."The randomized, double-blind, placebo-controlled phase 1b clinical trial evaluated the safety and tolerability of STP1, a combination of ibudilast and bumetanide, in ASD-Phen1 patients. The clinical trial (registered at clinicaltrials.gov NCT04644003), involved two 14-day treatment phases of ASD-Phen1 patients receiving STP1 or placebo.»...

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tmcnet

Research: More Intervention May Not Benefit Autistic Children | Mirage News 25/06/2024

«When a child is diagnosed with autism, healthcare professionals often recommend intensive interventions, which can amount to 20-40 hours per week to support their development.However, a new study led by Micheal Sandbank, PhD, assistant professor in the Department of Health Sciences at the UNC School of Medicine, and other researchers across the United States has found that more does not necessarily mean better.»...

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miragenews

Research: More Intervention May Not Benefit Autistic Children | Mirage News 25/06/2024

«When a child is diagnosed with autism, healthcare professionals often recommend intensive interventions, which can amount to 20-40 hours per week to support their development.However, a new study led by Micheal Sandbank, PhD, assistant professor in the Department of Health Sciences at the UNC School of Medicine, and other researchers across the United States has found that more does not necessarily mean better.»...

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miragenews

Protein-based homing device precisely delivers drugs to target neurons 21/06/2024

«Biomedical engineers at Duke University have developed a method to deliver drugs to specific types of neurons throughout the brain. This new approach, which was tested in mice, was 100 times more precise than existing methods and enables researchers to more effectively study neurological diseases and explore efficient, targeted drug treatments.»...

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medicalxpress

L'Etat condamne pour des heures de cours non remplacees : « Ils nous ont contraints d'en arriver la » - Le Parisien 19/05/2024


«A la veille du Congrès national de la fédération des conseils de parents d'élèves (FCPE), le président de la section des Hauts-de-Seine revient sur la condamnation inédite de l'Etat par le tribunal administratif de Cergy-Pontoise pour «Â carence dans l'organisation du service public de l'enseignement ». Les familles de cinq collégiens de Villeneuve-la-Garenne devraient être indemnisées.»...

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leparisien

Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings | Molecular Psychiatry 18/05/2024

«AbstractHomo sapiens and Neanderthals underwent hybridization during the Middle/Upper Paleolithic age, culminating in retention of small amounts of Neanderthal-derived DNA in the modern human genome. In the current study, we address the potential roles Neanderthal single nucleotide polymorphisms (SNP) may be playing in autism susceptibility in samples of black non-Hispanic, white Hispanic, and white non-Hispanic people using data from the Simons Foundation Powering Autism Research (SPARK), Genotype-Tissue Expression (GTEx), and 1000 Genomes (1000G) databases. We have discovered that rare variants are significantly enriched in autistic probands compared to race-matched controls. In addition, we have identified 25 rare and common SNPs that are significantly enriched in autism on different ethnic backgrounds, some of which show significant clinical associations. We have also identified other SNPs that share more specific genotype-phenotype correlations but which are not necessarily enriched in autism and yet may nevertheless play roles in comorbid phenotype expression (e.g., intellectual disability, epilepsy, and language regression). These results strongly suggest Neanderthal-derived DNA is playing a significant role in autism susceptibility across major populations in the United States»...

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nature