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MyBotsBlog -2M report
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| Depakine : Sanofi condamne a indemniser la lanceuse d'alerte Marine Martin apres douze ans de procedure |
10/09/2024 |
«Le tribunal judiciaire de Paris a condamné le laboratoire à verser à cette mère et à ses deux enfants près de 285 000 euros d'indemnités pour «défaut d'information » sur les risques de malformation et neurodéveloppementaux causés par le produit « défectueux » commercialisé par le laboratoire.»...
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lemonde |
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| Targeting the Circadian Modulation: Novel Therapeutic Approaches in the Management of ASD |
09/09/2024 |
«Circadian dysfunction is prevalent in neurodevelopmental disorders, particularly in autism spectrum disorder (ASD). A plethora of empirical studies demonstrate a strong correlation between ASD and circadian disruption, suggesting that modulation of circadian rhythms and the clocks could yield satisfactory advancements.
Research indicates that circadian dysfunction associated with abnormal neurodevelopmental phenotypes in ASD individuals, potentially contribute to synapse plasticity disruption.
Therefore, targeting circadian rhythms may emerge as a key therapeutic approach. In this study, we did a brief review of the mammalian circadian clock, and the correlation between the circadian mechanism and the pathology of ASD at multiple levels.
In addition, we highlight that circadian is the target or modulator to participate in the therapeutic approaches in the management of ASD, such as phototherapy, melatonin, modulating circadian components, natural compounds, and chronotherapies.
A deep understanding of the circadian clock's regulatory role in the neurodevelopmental phenotypes in ASD may inspire novel strategies for improving ASD treatment.»...
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frontiersin |
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| Early Brain Changes May Trigger Autism - Neuroscience News |
23/08/2024 |
«Summary: Researchers have uncovered critical insights into how autism spectrum disorders (ASD) may develop at early stages of brain formation. Using mouse models, the team discovered that environmental factors causing autism-like symptoms are linked to early changes in neurotransmitter activity in the brain.Specifically, they observed that a temporary switch from the inhibitory neurotransmitter GABA to the excitatory neurotransmitter glutamate in neonatal mice could lead to the development of ASD-like behaviors, such as repetitive actions and reduced social interaction, later in life.
By intervening during this early stage and reversing the neurotransmitter switch, the researchers were able to prevent the onset of these behaviors in adulthood.»...
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neurosciencenews |
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| Early Brain Changes May Trigger Autism - Neuroscience News |
23/08/2024 |
«Summary: Researchers have uncovered critical insights into how autism spectrum disorders (ASD) may develop at early stages of brain formation. Using mouse models, the team discovered that environmental factors causing autism-like symptoms are linked to early changes in neurotransmitter activity in the brain.Specifically, they observed that a temporary switch from the inhibitory neurotransmitter GABA to the excitatory neurotransmitter glutamate in neonatal mice could lead to the development of ASD-like behaviors, such as repetitive actions and reduced social interaction, later in life.
By intervening during this early stage and reversing the neurotransmitter switch, the researchers were able to prevent the onset of these behaviors in adulthood.»...
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neurosciencenews |
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| Dysregulation of parvalbumin expression and neurotransmitter imbalance in the auditory cortex of the BTBR mouse model of autism spectrum disorder. |
12/08/2024 |
«Individuals diagnosed with autism spectrum disorder (ASD) frequently exhibit abnormalities in auditory perception, a phenomenon potentially attributed to alterations in the excitatory and inhibitory cells constituting cortical circuits.
However, the exact genetic factors and cell types affected by ASD remain unclear. The present study investigated the balance of excitatory and inhibitory activity in the auditory cortex using BTBR T Itpr3/J (BTBR) mice, a well-established model for autism research.
Our investigation unveiled a reduction in parvalbumin-positive (PV) neurons within the AC of BTBR mice. Remarkably, in vivo magnetic resonance spectroscopy studies disclosed an elevation in glutamate (Glu) levels alongside a decrement in γ-aminobutyric acid (GABA) levels in this cortical region.
Additionally, transcriptomic analysis of the mouse model facilitated the classification of several ASD-associated genes based on their cellular function and pathways. By comparing autism risk genes with RNA transcriptome sequencing data from the ASD mouse model, we identified the recurrent target gene Scn1a and performed validation.
Intriguingly, we uncovered the specific expression of Scn1a in cortical inhibitory neurons. These findings hold significant value for understanding the underlying neural mechanisms of abnormal sensory perception in animal models of ASD.»...
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physiciansweekly |
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| Dysregulation of parvalbumin expression and neurotransmitter imbalance in the auditory cortex of the BTBR mouse model of autism spectrum disorder. |
12/08/2024 |
«Individuals diagnosed with autism spectrum disorder (ASD) frequently exhibit abnormalities in auditory perception, a phenomenon potentially attributed to alterations in the excitatory and inhibitory cells constituting cortical circuits.
However, the exact genetic factors and cell types affected by ASD remain unclear. The present study investigated the balance of excitatory and inhibitory activity in the auditory cortex using BTBR T Itpr3/J (BTBR) mice, a well-established model for autism research.
Our investigation unveiled a reduction in parvalbumin-positive (PV) neurons within the AC of BTBR mice. Remarkably, in vivo magnetic resonance spectroscopy studies disclosed an elevation in glutamate (Glu) levels alongside a decrement in γ-aminobutyric acid (GABA) levels in this cortical region.
Additionally, transcriptomic analysis of the mouse model facilitated the classification of several ASD-associated genes based on their cellular function and pathways. By comparing autism risk genes with RNA transcriptome sequencing data from the ASD mouse model, we identified the recurrent target gene Scn1a and performed validation.
Intriguingly, we uncovered the specific expression of Scn1a in cortical inhibitory neurons. These findings hold significant value for understanding the underlying neural mechanisms of abnormal sensory perception in animal models of ASD.»...
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physiciansweekly |
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| A study finds that autistic children do not perceive concepts through language |
26/07/2024 |
«For the first time the Lindy Lab group has explored the effect of linguistic labelling in autistic children. The results of the study suggest that autistic children do not perceive concepts through language, so they have difficulty inferring that two objects given the same name form a category.
In this respect, the need for further research into the relationship between language and concepts in the autistic mind is stressed."The autistic child population does not expect two objects, simply because they merely share a name, to have common properties or are the same type of object.
They are not sensitive to categorisation through the language they are being offered," said AgustÃn Vicente, Ikerbasque Research Professor and researcher in the UPV/EHU's Lindy Lab group.
"If the autistic population displays difficulties in deducing that two objects with the same name form a category, they may tend to generate concepts that do not coincide with those of the rest of the children and this may lead to difficulties in communication, among other things," added Vicente.»...
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alphagalileo |
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| A study finds that autistic children do not perceive concepts through language |
26/07/2024 |
«For the first time the Lindy Lab group has explored the effect of linguistic labelling in autistic children. The results of the study suggest that autistic children do not perceive concepts through language, so they have difficulty inferring that two objects given the same name form a category.
In this respect, the need for further research into the relationship between language and concepts in the autistic mind is stressed."The autistic child population does not expect two objects, simply because they merely share a name, to have common properties or are the same type of object.
They are not sensitive to categorisation through the language they are being offered," said AgustÃn Vicente, Ikerbasque Research Professor and researcher in the UPV/EHU's Lindy Lab group.
"If the autistic population displays difficulties in deducing that two objects with the same name form a category, they may tend to generate concepts that do not coincide with those of the rest of the children and this may lead to difficulties in communication, among other things," added Vicente.»...
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alphagalileo |
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